I am Dr. Dirgha Raj Joshi, a pharmacist and medicinal chemist with a BS in Pharmacy (Pokhara University, Nepal), MS in Medicinal Chemistry (Wonkwang University, South Korea), and a PhD in Medicinal Chemistry (Yonsei University, South Korea).
My research focuses on drug discovery, synthetic methodologies, and antiviral drug development, with 30+ publications and multiple patents. Currently, I serve as an Assistant Professor of Medicinal Chemistry at Karnali Academy of Health Sciences (KAHS), Nepal, and I welcome research collaborations.
"जुन देशका युवाले आफ्नै देशमा आफ्नो भविष्य देख्दैनन्, त्यो देशको भविष्य कहिल्यै उज्वल हुँदैन l "
Regioselective Synthesis of 1-Cyano-3-arylindolizines: Construction of Pyrroles via DDQ-Mediated Ring Closure of Cyclopropyl Pyridines
A modular approach to a wide range of 1-cyano-3-(hetero)arylindolizines through aldol-cyclopropanation-oxidative cycloisomerization is described where DDQ was utilized for the regioselective synthesis of the pyrrole units from cyclopropyl pyridines for the first time.
Synthesis of Poly-Functionalized Indolizines via [5+1] Annulative Access to Pyridines
Multi-functionalization of the pyridine motif of indolizine was achieved through [5+1] annulative construction of pyridine from 2-hydroxyacetophenone and pyrrole derivative in the presence of Cs2CO3.
Domino [4 + 2] Annulation Access to Quinone–Indolizine Hybrids: Anticancer N-Fused Polycycles
A highly efficient synthetic route to new quinone–indolizine hybrids was accomplished from quinones and N-substituted pyrrole-2-carboxaldehydes via a domino Michael addition-aldol condensation-aromatization sequence through which the central pyridine ring was constructed in atom-economical and environment-friendly manner
PUBLICATION IN NEWSPAPER
Korea, the world's biggest investor in research.
With improving economic conditions, Asian nations are spending a lot of resources in hopes of winning Nobel prizes, but they will need more than cash to realize their ambitions…
Message to President Moon
When Moon Jae-in was elected as the 19th president of South Korea there were so many hopes among Koreans as well as the foreigners staying in Korea for study, jobs, business, or permanent residents of foreign nationality.
Covid-19 response: Can Nepal learn from South Korea?
Instead of imposing a nationwide lockdown, South Korea enabled itself to better manage the Covid-19 pandemic with different, effective, and systematic strategies and received applause from the world…
