{
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        "rendered": "<div data-elementor-type=\"wp-page\" data-elementor-id=\"1998\" class=\"elementor elementor-1998\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c4d0f17 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c4d0f17\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8e5b769\" data-id=\"8e5b769\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-55890b2 elementor-widget elementor-widget-shortcode\" data-id=\"55890b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><style type='text\/css' media='all'>#rt-tpg-container-2257067991 .rt-holder .rt-woo-info .price{color:#0367bf;}body .rt-tpg-container .rt-tpg-isotope-buttons .selected,\n\t\t\t\t\t#rt-tpg-container-2257067991 .layout12 .rt-holder:hover .rt-detail,\n\t\t\t\t\t#rt-tpg-container-2257067991 .isotope8 .rt-holder:hover .rt-detail,\n\t\t\t\t\t#rt-tpg-container-2257067991 .carousel8 .rt-holder:hover .rt-detail,\n\t\t\t\t\t#rt-tpg-container-2257067991 .layout13 .rt-holder .overlay .post-info,\n\t\t\t\t\t#rt-tpg-container-2257067991 .isotope9 .rt-holder .overlay .post-info,\n\t\t\t\t\t#rt-tpg-container-2257067991.rt-tpg-container .layout4 .rt-holder .rt-detail,\n\t\t\t\t\t.rt-modal-2257067991 .md-content,\n\t\t\t\t\t.rt-modal-2257067991 .md-content > .rt-md-content-holder .rt-md-content,\n\t\t\t\t\t.rt-popup-wrap-2257067991.rt-popup-wrap .rt-popup-navigation-wrap,\n\t\t\t\t\t#rt-tpg-container-2257067991 .carousel9 .rt-holder .overlay .post-info{background-color:#0367bf;}#rt-tpg-container-2257067991 .layout5 .rt-holder .overlay, #rt-tpg-container-2257067991 .isotope2 .rt-holder .overlay, #rt-tpg-container-2257067991 .carousel2 .rt-holder .overlay,#rt-tpg-container-2257067991 .layout15 .rt-holder h3, #rt-tpg-container-2257067991 .isotope11 .rt-holder h3, #rt-tpg-container-2257067991 .carousel11 .rt-holder h3, #rt-tpg-container-2257067991 .layout16 .rt-holder h3,\n\t\t\t\t\t#rt-tpg-container-2257067991 .isotope12 .rt-holder h3, #rt-tpg-container-2257067991 .carousel12 .rt-holder h3 {background-color:rgba(3,103,191,0.8);}#rt-tpg-container-2257067991 .read-more a{border-radius:px;}#rt-tpg-container-2257067991 .rt-img-holder img.rt-img-responsive,#rt-tpg-container-2257067991 .rt-img-holder,\n\t\t\t\t\t#rt-tpg-container-2257067991 .rt-post-overlay .post-img,\n\t\t\t\t\t#rt-tpg-container-2257067991 .post-sm .post-img,\n\t\t\t\t\t#rt-tpg-container-2257067991 .rt-post-grid .post-img,\n\t\t\t\t\t#rt-tpg-container-2257067991 .post-img img {border-radius:px;}<\/style><div class='rt-container-fluid rt-tpg-container tpg-shortcode-main-wrapper' id='rt-tpg-container-2257067991'   data-layout='layout12' data-grid-style='even' data-desktop-col='2'  data-tab-col='2'  data-mobile-col='1' data-sc-id='2137'><div data-title='Loading ...' class='rt-row rt-content-loader   layout12 tpg-even'><div class=\"rt-col-md-6 rt-col-sm-6 rt-col-xs-12 even-grid-item rt-grid-item\" data-id=\"2565\"><div class=\"rt-holder\"><div class='rt-detail'><div class='post-meta-user'><span class='date-meta'><i class='far fa-calendar-alt'><\/i>December 3, 2022<\/span><span class='categories-links'><i class='fas fa-folder-open'><\/i><a class=\"research-article\" href=\"https:\/\/dirghajoshi.com.np\/en\/category\/research\/research-outcome\/journal-publication\/research-article\/\" rel=\"tag\">Research Article<\/a><\/span><\/div><h3 class=\"entry-title\"><a data-id=\"2565\" class=\"\" href=\"https:\/\/dirghajoshi.com.np\/en\/solvent-controlled-divergent-syntheses-of-polycyclic-n-fused-heteroaromatics-synthesis-2020-52192841-56-2\/\">Solvent-Controlled Divergent Syntheses of Polycyclic N-Fused Heteroaromatics (Synthesis. 2020, 52(19):2841-56)<\/a><\/h3><div class='tpg-excerpt'>\n<p><style>\/*! elementor - v3.9.0 - 06-12-2022 *\/<br \/>\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]&gt;a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865#\">Authors: Anuradha Dagar, Dirgha Raj Joshi , Ikyon Kim\u2217<\/a><\/h6>\n\n\n\n<p><style>\/*! elementor - v3.9.0 - 06-12-2022 *\/<br \/>\n.elementor-widget-image-box .elementor-image-box-content{width:100%}@media (min-width:768px){.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper,.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{display:flex}.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{text-align:right;flex-direction:row-reverse}.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper{text-align:left;flex-direction:row}.elementor-widget-image-box.elementor-position-top .elementor-image-box-img{margin:auto}.elementor-widget-image-box.elementor-vertical-align-top .elementor-image-box-wrapper{align-items:flex-start}.elementor-widget-image-box.elementor-vertical-align-middle .elementor-image-box-wrapper{align-items:center}.elementor-widget-image-box.elementor-vertical-align-bottom .elementor-image-box-wrapper{align-items:flex-end}}@media (max-width:767px){.elementor-widget-image-box .elementor-image-box-img{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-image-box .elementor-image-box-img{display:inline-block}.elementor-widget-image-box .elementor-image-box-title a{color:inherit}.elementor-widget-image-box .elementor-image-box-wrapper{text-align:center}.elementor-widget-image-box .elementor-image-box-description{margin:0}<\/style><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865#\"><img decoding=\"async\" src=\"https:\/\/dirghajoshi.com.np\/wp-content\/uploads\/2022\/12\/i_g0189_ga_10-1055_s-0040-1707865.gif\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><a href=\"http:\/\/thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865#'\">Abstract<\/a><\/h4>\n\n\n\n<p>Due to a growing interest in aza-fused polyaromatic systems among various sciences, enormous attention has been continuously paid to designing and synthesizing novel chemotypes of N-fused hetero\u00adcycles. During the course of continued efforts in this line, it was found that divergent access to new polycyclic N-fused heteroaromatics was enabled by the choice of reaction solvent. Described herein are solvent-controlled selective approaches to three novel N-fused azacycles, benzo-[d]imidazole-pyrrolo[1,2-a]pyrazine hybrids, under mild conditions. The plausible reaction mechanism for each class of compound is suggested as well.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-25 is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865#\" target=\"_blank\" rel=\"noreferrer noopener\">Read More<\/a><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><div class=\"rt-col-md-6 rt-col-sm-6 rt-col-xs-12 even-grid-item rt-grid-item\" data-id=\"2624\"><div class=\"rt-holder\"><div class='rt-detail'><div class='post-meta-user'><span class='date-meta'><i class='far fa-calendar-alt'><\/i>December 5, 2022<\/span><span class='categories-links'><i class='fas fa-folder-open'><\/i><a class=\"research-article\" href=\"https:\/\/dirghajoshi.com.np\/en\/category\/research\/research-outcome\/journal-publication\/research-article\/\" rel=\"tag\">Research Article<\/a><\/span><\/div><h3 class=\"entry-title\"><a data-id=\"2624\" class=\"\" href=\"https:\/\/dirghajoshi.com.np\/en\/research-output-as-part-of-phd-work\/\">Research output as part of PhD work<\/a><\/h3><div class='tpg-excerpt'>\n<ol class=\"wp-block-list\" type=\"1\">\n<li>Synthesis of Poly-Functionalized Indolizines via [5+1] Annulative Access to Pyridines (<em>Adv. syn. Cat., 2021, 363, 23, 5330-5335<\/em>).<\/li>\n\n\n\n<li>Regioselective Synthesis of 1-Cyano-3-arylindolizines: Construction of Pyrrole via DDQ-Mediated Ring Closure of Cyclopropyl Pyridines<\/li>\n\n\n\n<li>Domino [4 + 2] Annulation Access to Quinone\u2013Indolizine Hybrids: Anticancer N-Fused Polycycles (J. Org. Chem. 2020, 85, 16, 10994-1005).<\/li>\n\n\n\n<li> Michael-Aldol-Double Elimination Cascade to Make Pyridines: Use of Chromone for the Synthesis of Indolizines (<em>J. Org. Chem.<\/em> <em>2021, 86, 15, 10235\u201310248<\/em>). (<em>Adv. Synth. Cat., 2022, July 25<\/em>).<\/li>\n\n\n\n<li> <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2020\/ob\/d0ob01715a\">One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space<\/a> (<em>Org. Biomol. Chem., 2020,18, 8119-8140<\/em>).<\/li>\n\n\n\n<li>\u00a0 <a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1706089\">Facile Access to 3, 4-Disubstituted <em>2H-<\/em>Chromenes via Domino [4+ 2] Annulation<\/a> (<em>Synthesis 2021; 53(08): 1503-1512<\/em>).<\/li>\n\n\n\n<li><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865\">Solvent-Controlled Divergent Syntheses of Polycyclic <em>N<\/em>-Fused Heteroaromatics<\/a> (<em>Synthesis. 2020, 52(19):2841-56<\/em>).<\/li>\n\n\n\n<li>Benzofuro [2, 3-c] isoquinolines as novel AIEgens: Modulation of AIE characteristics by a single methoxy group. (Dyes and Pigments. 2022 Jul 21:110584).<\/li>\n\n\n\n<li>&nbsp; Generation of a Poly-Functionalized Indolizine Scaffold and Its Anticancer Activity in Pancreatic Cancer Cells. (Bioorganic Chemistry. 2022; 126: 105877).<\/li>\n\n\n\n<li>BF<sub>3<\/sub>.OEt<sub>2<\/sub>-Catalyzed One-pot Three-component Access to Diarymethylazides (<em>Tetrahedron Letters. 2021, 67, 152820<\/em>).<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><div class=\"rt-col-md-6 rt-col-sm-6 rt-col-xs-12 even-grid-item rt-grid-item\" data-id=\"2629\"><div class=\"rt-holder\"><div class='rt-detail'><div class='post-meta-user'><span class='date-meta'><i class='far fa-calendar-alt'><\/i>December 5, 2022<\/span><span class='categories-links'><i class='fas fa-folder-open'><\/i><a class=\"research-article\" href=\"https:\/\/dirghajoshi.com.np\/en\/category\/research\/research-outcome\/journal-publication\/research-article\/\" rel=\"tag\">Research Article<\/a><\/span><\/div><h3 class=\"entry-title\"><a data-id=\"2629\" class=\"\" href=\"https:\/\/dirghajoshi.com.np\/en\/other-research-articles\/\">Other  research articles<\/a><\/h3><div class='tpg-excerpt'>\n<ol class=\"wp-block-list\" type=\"1\">\n<li>Detergent Use Practices in Nepal: A Cross-Sectional Online Survey. <em>Current Journal of Applied Science and Technology<\/em>. 2020 Dec 4:111-8. Doi: <a href=\"https:\/\/doi.org\/10.9734\/cjast\/2020\/v39i3631079\"><em>10.9734\/cjast\/2020\/v39i3631079<\/em><\/a><em>.<\/em><em><\/em><\/li>\n\n\n\n<li><a href=\"https:\/\/actascientific.com\/ASPS\/effect-of-health-insurance-program-in-social-security-in-kailali-district-nepal.php\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Health Insurance Program in Social Security in Kailali District, Nepal.<\/a> 2020; 4 (2): 1-5. <em>Acta Scientific Pharmaceutical Sciences.<\/em><em><\/em><\/li>\n\n\n\n<li>Study of In-vitro Antioxidant and Antibacterial activity of leaf extract of <em>Azadirachta indica<\/em>, and <em>Ocimum sanctum<\/em> in different organic solvents and Cow urine. <em>&nbsp;Journal of Drug Delivery and Therapeutics. <\/em>10.1-s (2020): 90-95. Doi: <em>10.22270\/jddt.v10i1-s.3908.<\/em><\/li>\n\n\n\n<li>Anti-urolithiatic Property of Crataeva nurvala Root and Bark from Nepal on Ethylene Glycol induced Urolithiatic Mice. <em>Journal of Pharmaceutical Sciences and Research<\/em>. 2020 May 1;12(5):658-62.<em><\/em><\/li>\n\n\n\n<li>Personal Hygiene and Sanitary Practices among the School Girls in Dhangadhi, Nepal. <em>advance.sagepub.com\/articles\/preprint. 2021.<\/em><em><\/em><\/li>\n\n\n\n<li><em>In-vitro<\/em> Comparison of Anti-urolithiatic Effect of Crataeva nurvala, Zea mays (Corn Silk) and Ayurvedic Formulation Neeri Tablet. <em>Int. J. Pharm. Sci. Rev. Res.,<\/em> 66(1), 2021; 07: 26-30.<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><div class=\"rt-col-md-6 rt-col-sm-6 rt-col-xs-12 even-grid-item rt-grid-item\" data-id=\"2106\"><div class=\"rt-holder\"><div class='rt-detail'><div class='post-meta-user'><span class='date-meta'><i class='far fa-calendar-alt'><\/i>November 26, 2022<\/span><span class='categories-links'><i class='fas fa-folder-open'><\/i><a class=\"journal-publication\" href=\"https:\/\/dirghajoshi.com.np\/en\/category\/research\/research-outcome\/journal-publication\/\" rel=\"tag\">Journal Publication<\/a><span class=\"rt-separator\">,<\/span><a class=\"research-article\" href=\"https:\/\/dirghajoshi.com.np\/en\/category\/research\/research-outcome\/journal-publication\/research-article\/\" rel=\"tag\">Research Article<\/a><\/span><\/div><h3 class=\"entry-title\"><a data-id=\"2106\" class=\"\" href=\"https:\/\/dirghajoshi.com.np\/en\/benzofuro-2-3-c-isoquinolines-as-novel-aiegens-modulation-of-aie-characteristics-by-a-single-methoxy-group\/\">Benzofuro [2, 3-c] isoquinolines as novel AIEgens: Modulation of AIE characteristics by a single methoxy group<\/a><\/h3><div class='tpg-excerpt'>\n<p><style>\/*! elementor - v3.8.1 - 13-11-2022 *\/<br \/>\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]&gt;a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S014372082200506X\">Authors: Suzi Kim, Jae hyun Park, Dirgha RajJoshi, Na Keum Lee, Hang Le Bich Pham, Linh Khanh Chung, Min Joo Kang, Young gwan Kim, Ikyon Kim, Jeeyeon Lee<\/a><\/h6>\n\n\n\n<p><style>\/*! elementor - v3.8.1 - 13-11-2022 *\/<br \/>\n.elementor-widget-image-box .elementor-image-box-content{width:100%}@media (min-width:768px){.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper,.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-image-box.elementor-position-top .elementor-image-box-img{margin:auto}.elementor-widget-image-box.elementor-vertical-align-top .elementor-image-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-image-box.elementor-vertical-align-middle .elementor-image-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-image-box.elementor-vertical-align-bottom .elementor-image-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-image-box .elementor-image-box-img{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-image-box .elementor-image-box-img{display:inline-block}.elementor-widget-image-box .elementor-image-box-title a{color:inherit}.elementor-widget-image-box .elementor-image-box-wrapper{text-align:center}.elementor-widget-image-box .elementor-image-box-description{margin:0}<\/style><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter is-resized\"><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0040-1707865\"><img decoding=\"async\" src=\"https:\/\/dirghajoshi.com.np\/wp-content\/uploads\/2022\/11\/bfiq-273x300.jpg\" alt=\"\" width=\"279\" height=\"300\" \/><\/a><\/figure>\n\n\n\n<p class=\"has-medium-font-size\" style=\"margin-top:var(--wp--preset--spacing--50);margin-right:0;margin-bottom:0;margin-left:0\">Abstract<\/p>\n\n\n\n<p>Here, we report benzofuro[2,3-c]isoquinolines (FiQ) as novel blue AIEgens, in which a -OMe group substituent plays a crucial role in modulating intermolecular interactions, inducing a marked increase in emission of up to 150- and 460-fold in the aggregate and solid states, respectively. Our single-crystal X-ray diffraction analysis revealed that the edge-to-face interactions among phenyl groups generate tight networks that rigidify the assembled structures, resulting in AIE.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-25 is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S014372082200506X\" target=\"_blank\" rel=\"noreferrer noopener\">Read More<\/a><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>",
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